What is a common manifestation of retinoblastoma?

Retinoblastoma, a malignant tumor of the retina that typically occurs in children, often presents with a yellowish-white reflex seen in the pupil, known as "leukocoria." This abnormal reflection can be observed in photographs taken with a flash, where instead of the normal red reflex from a healthy retina, a white or yellowish glow is detected. This reflects the tumor's interference with normal retinal function and is a key sign in the early detection of retinoblastoma.

While red-eye reflex can be indicative of healthy retinas, it is not a manifestation of retinoblastoma. Similarly, an increase in tear production and a cloudy cornea are not typically associated with the condition and are more indicative of other visual or ocular issues. Thus, the yellowish-white reflex in the pupil is a critical finding that healthcare providers look for when diagnosing retinoblastoma.