What pediatric neurological condition is associated with an increased risk of seizures?

Tuberous Sclerosis Complex is a genetic disorder that is characterized by the growth of non-malignant tumors in various organs, including the brain. This condition is associated with several neurological manifestations, particularly the development of seizures. Individuals with Tuberous Sclerosis often have cortical tubers—abnormal growths on the brain—which can disrupt normal electrical activity and lead to seizures. The risk of epilepsy is significantly heightened in children with this condition, with many experiencing seizures during childhood, sometimes even at an early age.

In contrast, while other conditions like Down Syndrome and Cerebral Palsy may have an association with seizures, the prevalence and connection in Tuberous Sclerosis Complex is particularly strong and notable. Spinal Muscular Atrophy primarily affects motor neurons and does not have a direct link to increased seizure activity. Therefore, recognizing the clear association between Tuberous Sclerosis Complex and seizures is essential for understanding this pediatric neurological condition.