Which vitamin deficiency is commonly associated with seizures in infants?

Vitamin B6 deficiency, also known as pyridoxine deficiency, is indeed commonly associated with seizures in infants. Inadequate levels of this vitamin can lead to the impaired synthesis of neurotransmitters, particularly gamma-aminobutyric acid (GABA), which plays a crucial role in regulating neuronal excitability. A lack of GABA can create an environment in the brain that is more susceptible to seizure activity.

In infants, symptoms of vitamin B6 deficiency can present as seizures that are resistant to typical anticonvulsant medications. Supplementation with vitamin B6 has been shown to terminate these seizures, highlighting the direct link between this deficiency and seizure episodes.

Other vitamin deficiencies, such as those related to vitamins A, C, and D, do not have a well-established role in the pathogenesis of seizures specifically in infants. Vitamin A is primarily involved in vision and immune function, while vitamin C is important for collagen synthesis and antioxidant protection. Vitamin D is crucial for bone health and calcium metabolism but does not directly relate to seizure activity in the same manner as vitamin B6.